Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants

Author:

Bricker Katherine M.1ORCID,Obregon-Perko Veronica1,Williams Brianna1,Oliver Danielle1,Uddin Ferzan1,Neja Margaret1,Hopkins Louis1,Dashti Amir1ORCID,Jean Sherrie23,Wood Jennifer S.2,Ehnert Stephanie2,Liang Shan2,Vanderford Thomas2,Tharp Gregory K.2,Bosinger Steven E.23,Schauer Amanda P.4,Mavigner Maud15ORCID,Cottrell Mackenzie L.4,Margolis David678910,Dunham Richard M.681112,Chahroudi Ann125ORCID

Affiliation:

1. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

2. Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA

3. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

4. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

5. Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA

6. Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

7. Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

8. UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

9. Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

10. Department of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

11. Qura Therapeutics, Chapel Hill, Research Triangle Park, North Carolina, USA

12. HIV Drug Discovery, ViiV Healthcare, Research Triangle Park, North Carolina, USA

Abstract

While antiretroviral therapy (ART) has improved HIV-1 disease outcome and reduced transmission, interruption of ART results in rapid viral rebound due to the persistent latent reservoir. Interventions to reduce the viral reservoir are of critical importance, especially for children who must adhere to lifelong ART to prevent disease progression.

Funder

HHS | National Institutes of Health

HHS / National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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