Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase from Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase from Klebsiella pneumoniae

Published:2008-10 Issue:10 Volume:52 Page:3792-3794
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dubois Véronique¹,Poirel Laurent²,Demarthe François¹,Arpin Corinne¹,Coulange Laure¹,Minarini Luciene A. R.²,Bezian Marie-Christine³,Nordmann Patrice²,Quentin Claudine¹

Affiliation:

1. UMR 5234, CNRS, Université de Bordeaux 2, Bordeaux

2. Service de Bactériologie-Virologie, INSERM U914: Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre

3. Laboratoire de Bactériologie, Hôpital Saint-André, Bordeaux, France

Abstract

ABSTRACT A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla SHV-56 , encoding a new inhibitor-resistant β-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00387-08

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