Quinupristin-Dalfopristin Nonsusceptibility in Pneumococci from Sickle Cell Disease Patients-Reference-Cited by-同舟云学术

Quinupristin-Dalfopristin Nonsusceptibility in Pneumococci from Sickle Cell Disease Patients

Published:2007-01 Issue:1 Volume:51 Page:386-389
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Obert Caroline A.¹,Miller Martha L.¹,Montgomery Jeremy¹,Adamkiewicz Thomas²,Tuomanen Elaine I.¹

Affiliation:

1. Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105

2. Department of Family Medicine, Morehouse School of Medicine, 1513 E. Cleveland, No. 100, East Point, Georgia 30344

Abstract

ABSTRACT Sickle cell disease (SCD) is a risk factor for fatal pneumococcal infection. Nonsusceptibilty to quinupristin-dalfopristin (Q-D) was absent from 105 non-SCD-associated pneumococcal isolates but was present in 33/148 (22%) SCD-associated isolates. One-third of the isolates harbored a known resistance mechanism. Q-D is not optimal for use for the treatment of pneumococcal infection in SCD patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01016-06

Reference30 articles.

1. Adamkiewicz, T. V., S. Sarnaik, G. R. Buchanan, R. V. Iyer, S. T. Miller, C. H. Pegelow, Z. R. Rogers, E. Vichinsky, J. Elliott, R. R. Facklam, K. L. O'Brien, B. Schwartz, C. A. Van Beneden, M. J. Cannon, J. R. Eckman, H. Keyserling, K. Sullivan, W. Y. Wong, and W. C. Wang. 2003. Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination. J. Pediatr.143:438-444.

2. Allignet, J., and N. El Solh. 1997. Characterization of a new staphylococcal gene, vgaB, encoding a putative ABC transporter conferring resistance to streptogramin A and related compounds. Gene202:133-138.

3. Diversity among the gram-positive acetyltransferases inactivating streptogramin A and structurally related compounds and characterization of a new staphylococcal determinant, vatB

4. Characterization of a Staphylococcal Plasmid Related to pUB110 and Carrying Two Novel Genes, vatC and vgbB , Encoding Resistance to Streptogramins A and B and Similar Antibiotics

5. Allignet, J., V. Loncle, and N. el Sohl. 1992. Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibiotics. Gene117:45-51.