Daptomycin Concentrations in Valve Tissue and Vegetation in Patients with Bacterial Endocarditis

Abstract

ABSTRACTIn a patient with mitral-aortic native-valveStreptococcus oralisendocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In the case of porcine-aortic-valveStaphylococcus epidermidisendocarditis, the daptomycin concentrations were 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations.S. epidermidiswas eradicated, whereasStreptococcus oralispersisted, and its daptomycin MIC displayed a 4-fold increase.