Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare bla CTX-M-24 -Harboring Virulence Plasmid-Reference-Cited by-同舟云学术

Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare bla CTX-M-24 -Harboring Virulence Plasmid

Published:2019-03 Issue:3 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shen Dingxia¹,Ma Guannan²,Li Cuidan²³,Jia Xinmiao⁴,Qin Chuan²³,Yang Tingting²³,Wang Lifeng¹,Jiang Xiaoyuan⁵,Ding Nan²,Zhang Xiuli²³,Yue Liya²,Yin Zhe⁵,Zeng Lijun⁵,Zhao Yongliang⁶,Zhou Dongsheng⁵,Chen Fei²³

Affiliation:

1. Center of Clinical Laboratory Medicine, Chinese General Hospital of PLA, Beijing, China

2. CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics Chinese Academy of Sciences, Beijing, China

3. University of Chinese Academy of Sciences, Beijing, China

4. Central Research Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

5. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

6. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

Abstract

Here, we report a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and bla CTX-M-24 , and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Further analysis indicates that the hybrid plasmid is formed by IS 903D -mediated intermolecular transposition of the bla CTX-M-24 gene into the virulence plasmid.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02273-18

Reference16 articles.

1. Hypervirulent (hypermucoviscous)Klebsiella pneumoniae

2. The genome of a clinicalKlebsiella variicolastrain reveals virulence-associated traits and a pl9-like plasmid

3. ESBL-Producing Strain of HypervirulentKlebsiella pneumoniaeK2, France