Maturation of the Translation Inhibitor Microcin C-Reference-Cited by-同舟云学术

Maturation of the Translation Inhibitor Microcin C

Published:2009-04 Issue:7 Volume:191 Page:2380-2387
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Metlitskaya Anastasia¹,Kazakov Teymur²³,Vondenhoff Gaston H.²⁴,Novikova Maria³,Shashkov Alexander⁵,Zatsepin Timofei⁶,Semenova Ekaterina²,Zaitseva Natalia⁷,Ramensky Vasily⁸,Van Aerschot Arthur⁴,Severinov Konstantin¹²³

Affiliation:

1. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia

2. Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers, the State University, Piscataway, New Jersey 08854

3. Institute of Gene Biology, Russian Academy of Sciences, Moscow 119991, Russia

4. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

5. Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia

6. Department of Chemistry, Moscow State University, Moscow 119991, Russia

7. Central Research Institute of Chemistry and Mechanics, Moscow 115487, Russia

8. Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow 119991, Russia

Abstract

ABSTRACT Microcin C (McC), an inhibitor of the growth of enteric bacteria, consists of a heptapeptide with a modified AMP residue attached to the backbone of the C-terminal aspartate through an N -acyl phosphamidate bond. Here we identify maturation intermediates produced by cells lacking individual mcc McC biosynthesis genes. We show that the products of the mccD and mccE genes are required for attachment of a 3-aminopropyl group to the phosphate of McC and that this group increases the potency of inhibition of the McC target, aspartyl-tRNA synthetase.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00999-08

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