Redondovirus Diversity and Evolution on Global, Individual, and Molecular Scales

Author:

Taylor Louis J.1ORCID,Dothard Marisol I.1,Rubel Meagan A.23,Allen Audrey A.14,Hwang Young1,Roche Aoife M.1,Graham-Wooten Jevon5,Fitzgerald Ayannah S.5,Khatib Layla A.5,Ranciaro Alessia3,Thompson Simon R.3,Beggs William R.3,Campbell Michael C.3,Mokone Gaonyadiwe G.6,Mpoloka Sununguko Wata7,Fokunang Charles8,Njamnshi Alfred K.910,Mbunwe Eric3,Woldemeskel Dawit11,Belay Gurja11,Nyambo Thomas12,Tishkoff Sarah A.313,Collman Ronald G.15ORCID,Bushman Frederic D.1ORCID

Affiliation:

1. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Anthropology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

5. Department of Medicine, Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

6. University of Botswana, Faculty of Medicine, Gaborone, Botswana

7. University of Botswana, Biological Sciences, Gaborone, Botswana

8. Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon

9. Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon

10. Brain Research Africa Initiative, Neuroscience Lab, Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon

11. Addis Ababa University, Department of Microbial Cellular and Molecular Biology, Addis Ababa, Ethiopia

12. Kampala International University in Tanzania, Dar es Salaam, Tanzania

13. Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Redondoviridae is a recently established family of DNA viruses predominantly found in the human respiratory tract and associated with multiple clinical conditions. In this study, we found high redondovirus prevalence in saliva from urban North American individuals and nonindustrialized African populations in Botswana, Cameroon, Ethiopia, and Tanzania.

Funder

American Diabetes Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | National Institutes of Health

National Science Foundation

Wenner-Gren Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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