TLR1/2 Agonist Enhances Reversal of HIV-1 Latency and Promotes NK Cell-Induced Suppression of HIV-1-Infected Autologous CD4 + T Cells-Reference-Cited by-同舟云学术

TLR1/2 Agonist Enhances Reversal of HIV-1 Latency and Promotes NK Cell-Induced Suppression of HIV-1-Infected Autologous CD4 + T Cells

Published:2021-08-10 Issue:17 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Duan Siqin¹,Xu Xinfeng¹,Wang Jinshen¹,Huang Liwen¹,Peng Jie²,Yu Tao²,Zhou Yang³,Cheng Kui¹,Liu Shuwen¹⁴^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China

2. Division of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China

3. Division of Infectious Diseases, Third People’s Hospital of Shenzhen, Shenzhen, China

4. State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou, China

Abstract

Multiple in vivo studies showed that many LRAs used in the shock-and-kill approach could activate viral transcription but could not induce killing effectively. Therefore, a dual-function LRA is needed for elimination of HIV-1 reservoirs.

Funder

MOST | National Science and Technology Infrastructure Program

National Natural Science Foundation of China

People’s Government of Guangdong Province | National Natural Science Foundation of China-Guangdong Joint Fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00816-21

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