Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants

Author:

Su Chao12,He Juanhua23,Han Pengcheng24,Bai Bin25,Li Dedong26,Cao Jian2,Tian Mingxiong27,Hu Yu28,Zheng Anqi24,Niu Sheng29,Chen Qian210,Rong Xiaoyu211,Zhang Yanfang2,Li Weiwei2,Qi Jianxun2ORCID,Zhao Xin212,Yang Mengsu1,Wang Qihui2,Gao George Fu123ORCID

Affiliation:

1. Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China

2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

3. College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang, China

4. College of Life Science and Technology, Southeast University, Nanjing, China

5. University of the Chinese Academy of Sciences, Beijing, China

6. College of Veterinary Medicine, China Agricultural University, Beijing, China

7. School of Life Sciences, Shanxi University, Taiyuan, China

8. School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China

9. College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China

10. Institutes of Physical Science and Information Technology, Anhui University, Hefei, China

11. School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China

12. CAS Center for Influenza Research and Early-Warning, Chinese Academy of Sciences, Beijing, China

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a broad range of hosts. Mink-derived SARS-CoV-2 can transmit back to humans.

Funder

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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