Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival-Reference-Cited by-同舟云学术

Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival

Published:2020-01-16 Issue:3 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Shu Wangqin¹,Guo Zhiwei¹,Li Lijie¹,Xiong Zhiqi²,Wang Ziyu¹,Yang Yuanyuan³,Li Yuqi¹,He Minjing¹,Gong Ruijie¹,Gao Bo¹

Affiliation:

1. Department of Immunology, Shanghai Medical College of Fudan University, Shanghai, People’s Republic of China

2. School of Life Science and Technology, Shanghai Tech University, People’s Republic of China

3. Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, People’s Republic of China

Abstract

Chronic hepatitis B (CHB) remains a global health problem, carrying a high risk for progression into cirrhosis and liver failure. Molecular chaperones are involved in diverse pathophysiological processes including viral infection. However, the role of molecular chaperones in hepatitis B virus (HBV) infection and its underlying mechanisms remain unclear. Here, we identified GRP78 as one of the molecular chaperones most strongly induced by HBV in human hepatocytes.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00475-19

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