Abstract
A strain of Neurospora crassa defective in amino acid transport can utilize a variety of amino acids for growth when readily metabolizable nitrogen is limiting. Growth is accompanied by the production of an extracellular deaminase that converts the amino acid to its respective keto acid plus equimolar quantities of utilizable nitrogen in the ammonium ion form. Production of the deaminase is subject to ammonium repression. The relationship between the ability of an amino acid to trigger deaminase production and the presence of particular amino acid permease deficiencies is complex. Four classes of amino acids have been defined with respect to this relationship. The existence of multiple extracellular deaminases is discussed.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference40 articles.
1. Regulation of proline transport in Aspergillus nidulans;Arst H. N.;J. Gen. Microbiol.,1980
2. The L-amino acid oxidase of Neurospora;Burton K.;Biochem. J.,1951
3. Regulation of exocellular protease in Neurospora crassa: induction and repression under conditions of nitrogen starvation;Cohen B. L.;Arch. Biochem. Biophys.,1977
4. Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae;Courchesne W. E.;Mol. Cell. Biol.,1983
5. Molecular transport in Neurospora crassa. I. Biochemical properties of a phenylalanine permease;DeBusk B. G.;Biochim. Biophys. Acta,1965
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献