Single-Oral-Dose Azithromycin Prophylaxis against Experimental Streptococcal or Staphylococcal Aortic Valve Endocarditis-Reference-Cited by-同舟云学术

Single-Oral-Dose Azithromycin Prophylaxis against Experimental Streptococcal or Staphylococcal Aortic Valve Endocarditis

Published:2000-06 Issue:6 Volume:44 Page:1754-1756
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tsitsika Artemis¹,Pefanis Angelos²,Perdikaris George S.¹,Donta Ismini³,Karayiannakos Panayiotis³,Giamarellou Helen¹

Affiliation:

1. Infectious Diseases Section, 4th Department of Medicine, Sismanoglion General Hospital,1 and

2. 3rd Department of Medicine, Sotiria General Hospital,2 and

3. Section of Experimental Surgery and Surgical Research, 2nd Department of Propedeutic Surgery, Laikon General Hospital,3 Athens University School of Medicine, Athens, Greece

Abstract

ABSTRACT Azithromycin and ampicillin protected 94 and 72% of animals challenged with Streptococcus oralis , respectively ( P = 0.177), while azithromycin and vancomycin protected 59 and 94% of the methicillin-resistant Staphylococcus aureus (MRSA)-challenged animals, respectively ( P = 0.018). Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.6.1754-1756.2000

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