Affiliation:
1. Department of Medicine, University of Massachusetts Medical Center, Worcester 01655.
Abstract
Antibody-dependent enhancement of the uptake of influenza A virus by Fc receptor-bearing cells was analyzed by using virus strains of the three human influenza A virus subtypes, A/PR/8/34 (H1N1), A/Japan/305/57 (H2N2), and A/Port Chalmers/1/73 (H3N2). Immune sera obtained from mice following primary infection with an H1N1, H2N2, or H3N2 subtype virus neutralized only virus of the same subtype; however, immune sera augmented the uptake of virus across subtypes. Immune sera from H1N1-infected mice augmented uptake of the homologous (H1N1) and H2N2 viruses. Antisera to the H2N2 virus augmented the uptake of virus of all subtypes (H1N1, H2N2, or H3N2). Antisera to the H3N2 virus augmented the uptake of the homologous (H3N2) and H2N2 viruses. These results show that subtype cross-reactive, nonneutralizing antibodies augment the uptake of influenza A virus strains of different subtypes. Antibodies to neuraminidase may contribute to the enhanced uptake of viruses of a different subtype, because N2-specific monoclonal antibodies augmented the uptake of both A/Japan/305/57 (H2N2) and A/Port Chalmers/1/73 (H3N2) viruses.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference29 articles.
1. Abbas A. K. A. H. Lichtman and J. S. Pober. 1991. Antigen presentation and T cell antigen recognition p. 115-137. In M. J. Wonsiewicz (ed.) Cellular and molecular immunology-1991. The W. B. Saunders Co. Philadelphia.
2. Studies with avian influenza A viruses: cross protection experiments in chickens;Allan W. H.;J. Gen. Virol.,1971
3. .Birmingham D. Personal communication.
4. Infection of a macrophage-like cell line, P388D, with reovirus; effects of immune ascitic fluids and monoclonal antibodies on neutralization and on enhancement of viral growth;Burstin S. J.;J. Immunol.,1983
5. Antibodies to hepatitis B surface antigen potentiate the response of human T Iymphocyte clones to the same antigen;Celis E.;Science,1984
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