Mixed Periodontal Th1-Th2 Cytokine Profile in Actinobacillus actinomycetemcomitans -Specific Osteoprotegerin Ligand (or RANK-L)- Mediated Alveolar Bone Destruction In Vivo-Reference-Cited by-同舟云学术

Mixed Periodontal Th1-Th2 Cytokine Profile in Actinobacillus actinomycetemcomitans -Specific Osteoprotegerin Ligand (or RANK-L)- Mediated Alveolar Bone Destruction In Vivo

Published:2002-09 Issue:9 Volume:70 Page:5269-5273
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Teng Yen-Tung A.¹²

Affiliation:

1. Division of Periodontics and Department of Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1

2. Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6A 4G5, Canada

Abstract

ABSTRACT The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans -mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.9.5269-5273.2002

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