The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies-Reference-Cited by-同舟云学术

The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies

Published:2002-09 Issue:9 Volume:70 Page:5328-5331
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Nwuba Roseangela I.¹,Sodeinde Olugbemiro²,Anumudu Chiaka I.¹,Omosun Yusuf O.¹,Odaibo Alexander B.¹,Holder Anthony A.³,Nwagwu Mark¹

Affiliation:

1. Cellular Parasitology Programme, Department of Zoology

2. Department of Paediatrics, University College Hospital, University of Ibadan, Ibadan, Nigeria

3. Division of Parasitology, National Institute for Medical Research, London NW7 1AA, United Kingdom

Abstract

ABSTRACT Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.9.5328-5331.2002

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