Combination Therapy with Amphotericin B Lipid Complex and Caspofungin Acetate of Disseminated Zygomycosis in Diabetic Ketoacidotic Mice-Reference-Cited by-同舟云学术

Combination Therapy with Amphotericin B Lipid Complex and Caspofungin Acetate of Disseminated Zygomycosis in Diabetic Ketoacidotic Mice

Published:2005-02 Issue:2 Volume:49 Page:830-832
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Spellberg Brad¹,Fu Yue¹,Edwards John E.¹,Ibrahim Ashraf S.¹

Affiliation:

1. Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, and David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California

Abstract

ABSTRACT We studied the combination of amphotericin B lipid complex (ABLC) and caspofungin in mice with disseminated Rhizopus oryzae . Combination therapy improved survival compared to that of mice given monotherapy and that of untreated controls ( P < 0.05) but did not improve organ clearance. In addition, prophylactic combination therapy was not more effective than prophylactic ABLC alone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.2.830-832.2005

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