Transient Neonatal Cryptosporidium parvum Infection Triggers Long-Term Jejunal Hypersensitivity to Distension in Immunocompetent Rats-Reference-Cited by-同舟云学术

Transient Neonatal Cryptosporidium parvum Infection Triggers Long-Term Jejunal Hypersensitivity to Distension in Immunocompetent Rats

Published:2006-07 Issue:7 Volume:74 Page:4387-4389
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Marion Rachel¹,Baishanbo Asiya¹²,Gargala Gilles¹,François Arnaud³,Ducrotté Philippe¹,Duclos Celia³,Fioramonti Jean⁴,Ballet Jean Jacques⁵,Favennec Loïc¹

Affiliation:

1. Laboratoire de Parasitologie and ADEN UPRES EA-3234, CHU Charles-Nicolle, 76031 Rouen, France

2. College of Pharmacy, Xinjiang Medical University, Urumqi, China

3. Laboratoire d'Histopathologie, CHU Charles Nicolle, Rouen, France

4. INRA, 180 Chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 9, France

5. Laboratoire d'Immunologie et Immunopathologie, UPRES EA-2128, CHU Clemenceau, Caen, France

Abstract

ABSTRACT In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10 2 or 10 5 Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity ( P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity ( P < 0.001) but not myeloperoxidase levels ( P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.02055-05

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