Type I Interferon Acts as a Major Barrier to the Establishment of Persistent Infectious Bursal Disease Virus Infections

Author:

Broto Laura1,Romero Nicolás1,Méndez Fernando1,Diaz-Beneitez Elisabet1,Candelas-Rivera Oscar1,Fuentes Daniel1,Cubas-Gaona Liliana L.1,Courtillon Céline2,Eterradossi Nicolas2,Soubies Sébastien M.2,Rodríguez Juan R.1,Rodríguez Dolores1ORCID,Rodríguez José F.1ORCID

Affiliation:

1. Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain

2. OIE Reference Laboratory for Gumboro Disease, Avian and Rabbit Virology, Immunology and Parasitology Unit (VIPAC), French Agency for Food, Environmental and Occupational Health Safety (ANSES), Ploufragan, France

Abstract

Members of the Birnaviridae family, including infectious bursal disease virus (IBDV), exhibit a dual behavior, causing acute infections that are often followed by the establishment of lifelong persistent asymptomatic infections. Indeed, persistently infected specimens might act as efficient virus reservoirs, potentially contributing to virus dissemination.

Funder

Caixa Foundation

Comunidad Autónoma de Madrid

Ministerio de Economía y Competitividad

MEC | Agencia Estatal de Investigación

Ministerio de Ciencia, Innovación y Universidades

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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