Biological Evaluation and Mechanistic Studies of Quinolin-(1 H )-Imines as a New Chemotype against Leishmaniasis-Reference-Cited by-同舟云学术

Biological Evaluation and Mechanistic Studies of Quinolin-(1 H )-Imines as a New Chemotype against Leishmaniasis

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gomes-Alves Ana Georgina¹²³,Duarte Margarida¹²,Cruz Tânia¹²,Castro Helena¹²,Lopes Francisca⁴^ORCID,Moreira Rui⁴,Ressurreição Ana S.⁴,Tomás Ana M.¹⁵^ORCID

Affiliation:

1. i3S, Instituto de Investigação e Inovação em Saúde, Porto, Portugal

2. IBMC, Instituto de Biologia Molecular e Celular, Porto, Portugal

3. Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal

4. iMed.ULisboa, Research Institute for Medicines, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal

5. ICBAS, School of Medicine and Biomedical Sciences, Universidade do Porto, Porto, Portugal

Abstract

Leishmaniasis is one of the most challenging neglected tropical diseases and remains a global threat to public health. Currently available therapies for leishmaniases present significant drawbacks and are rendered increasingly inefficient due to parasite resistance, making the need for more effective, safer, and less expensive drugs an urgent one.

Funder

EC | European Regional Development Fund

MEC | Fundação para a Ciência e a Tecnologia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01513-20

Reference31 articles.

1. Leishmaniasis in high-burden countries: an epidemiological update based on data reported in 2014;World Health Organization;Wkly Epidemiol Rec,2016

2. Chemotherapy of leishmaniasis: present challenges