CTX-M-33 Is a CTX-M-15 Derivative Conferring Reduced Susceptibility to Carbapenems-Reference-Cited by-同舟云学术

CTX-M-33 Is a CTX-M-15 Derivative Conferring Reduced Susceptibility to Carbapenems

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Poirel Laurent¹²³,de la Rosa José-Manuel Ortiz¹,Richard Anaïs¹,Aires-de-Sousa Marta⁴,Nordmann Patrice¹²³⁵

Affiliation:

1. Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland

2. INSERM European Unit, IAME, Paris, France

3. Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland

4. Escola Superior de Saúde da Cruz Vermelha Portuguesa, Lisbon, Portugal

5. University of Lausanne, University Hospital Center, Lausanne, Switzerland

Abstract

CTX-M-type extended-spectrum β-lactamases (ESBLs) are widespread among Enterobacterales strains worldwide. The most common variant is CTX-M-15, which hydrolyzes ceftazidime at a high rate but spares carbapenems. Here, we identified CTX-M-33, a point mutation derivative of CTX-M-15 (Asp to Ser substitution at Ambler position 109) that exhibited low carbapenemase activity.

Funder

University of Fribourg

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01515-19

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