PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens

Author:

Euler Chad W.1234,Raz Assaf23,Hernandez Anaise23,Serrano Anna2,Xu Siyue125,Andersson Martin26,Zou Geng1,Zhang Yue1,Fischetti Vincent A.2,Li Jinquan12ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China

2. Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA

3. Department of Medical Laboratory Sciences, Hunter College, CUNY, New York, New York, USA

4. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

5. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China

6. Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden

Abstract

Klebsiella pneumoniae and Pseudomonas aeruginosa are two leading causes of burn and wound infections, pneumonia, urinary tract infections, and more severe invasive diseases, which are often multidrug resistant (MDR) or extensively drug resistant. Due to this, it is critical to discover alternative antimicrobials, such as bacteriophage lysins, against these pathogens.

Funder

MOST | National Key Research and Development Program of China

Rockefeller University

Hunter College, CUNY

National Natural Science Foundation of China

Special Fund for Technology Innovation of Hubei Province

The Natural Science Foundation of Hubei Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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