Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector-Reference-Cited by-同舟云学术

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Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector

Published:2012-03-07 Issue:10 Volume:86 Page:5719-5729
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:Journal of Virology

Author:

Walker J. E.,Chen R. X.,McGee J.,Nacey C.,Pollard R. B.,Abedi M.,Bauer G.,Nolta J. A.,Anderson J. S.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference29 articles.

1. Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates;An;Proc. Natl. Acad. Sci. U. S. A.,2007

2. Safety and efficacy of a lentiviral vector containing three anti-HIV genes—CCR5 ribozyme, tat-rev siRNA, and TAR decoy—in SCID-hu mouse-derived T cells;Anderson;Mol. Ther.,2007

3. Complete knockdown of CCR5 by lentiviral vector-expressed siRNAs and protection of transgenic macrophages against HIV-1 infection;Anderson;Gene Ther.,2007

4. Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5alpha (TRIM 5alpha) in CD34+(+) cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue;Anderson;Hum. Gene Ther.,2008

5. Preintegration HIV-1 inhibition by a combination lentiviral vector containing a chimeric TRIM5alpha protein, a CCR5 shRNA, and a TAR decoy;Anderson;Mol. Ther.,2009

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