Systematic Evaluation of Mycobacterium tuberculosis Proteins for Antigenic Properties Identifies Rv1485 and Rv1705c as Potential Protective Subunit Vaccine Candidates-Reference-Cited by-同舟云学术

Systematic Evaluation of Mycobacterium tuberculosis Proteins for Antigenic Properties Identifies Rv1485 and Rv1705c as Potential Protective Subunit Vaccine Candidates

Published:2021-02-16 Issue:3 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wang Yaguo¹²,Li Zihui³,Wu Shucai⁴,Fleming Joy¹,Li Chuanyou³,Zhu Guofeng¹,Chen Bo¹,Ren Baiguang¹,Wang Xingyun¹,Du Boping³,Li Pingjun¹,Hu Peilei¹,Yang Juwang¹,Liu Yi³,Zhou Chongchen⁵,Zhang Xian-En⁶⁷,Bi Lijun¹⁶⁷⁸,Zhang Hongtai¹^ORCID,Yang Junmei⁵,Zhang Zongde³

Affiliation:

1. Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China

4. Hebei Chest Hospital, Shijiazhuang, China

5. Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province, China

6. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

7. School of Stomatology and Medicine, Foshan University, Foshan, Guangdong Province, China

8. Guangdong Province Key Laboratory of TB Systems Biology and Translational Medicine, Foshan, Guangdong Province, China

Abstract

The lack of efficacious vaccines against Mycobacterium tuberculosis (MTB) infection is a limiting factor in the prevention and control of tuberculosis (TB), the leading cause of death from an infectious agent. Improvement or replacement of the BCG vaccine with one that reliably protects all age groups is urgent.

Funder

The Strategic Priority Research Program of the Chinese Academy of Sciences

The National Key Research and Development Program of China

The National Science and Technology Major Project

The National Natural Science Foundation of China

The International Partnership Program of the Chinese Academy of Sciences

The Special Fund for Public Welfare Research and Capacity Building in Guangdong Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00585-20

Reference67 articles.

1. World Health Organization. 2019. Global tuberculosis report 2018. WHO, Geneva, Switzerland.

2. STOP TB Partnership. 2020. The TB response is heavily impacted by the COVID-19 pandemic. http://www.stoptb.org/news/stories/2020/ns20_014.html. Accessed 8 December 2020.

3. Predicted impact of the COVID-19 pandemic on global tuberculosis deaths in 2020

4. Progress and challenges in TB vaccine development

5. Novel vaccine candidates against Mycobacterium tuberculosis

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