Effect of Phosphatase Activity of the Control of Virulence Sensor (CovS) on Clindamycin-Mediated Streptolysin O Production in Group A Streptococcus-Reference-Cited by-同舟云学术

Effect of Phosphatase Activity of the Control of Virulence Sensor (CovS) on Clindamycin-Mediated Streptolysin O Production in Group A Streptococcus

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chiang-Ni Chuan¹²³^ORCID,Tseng Huei-Chuan¹,Shi Yong-An²,Chiu Cheng-Hsun²³⁴

Affiliation:

1. Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan

2. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan

3. Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

4. Department of Pediatrics, Chang Gung Children’s Hospital, Taoyuan, Taiwan

Abstract

Severe manifestations of group A Streptococcus (GAS) infections are associated with massive tissue destruction and high mortality. Clindamycin (CLI), a bacterial protein synthesis inhibitor, is recommended for treating patients with severe invasive GAS infection. Nonetheless, the subinhibitory concentration of CLI induces the production of GAS virulent exoproteins, such as streptolysin O (SLO) and NADase, which would enhance bacterial virulence and invasiveness.

Funder

Ministry of Science and Technology, Taiwan

Chang Gung Memorial Hospital, Linkou

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00583-19

Reference33 articles.

1. Necrotizing Soft-Tissue Infections

2. Editorial Commentary: Step on the GAS: Are We Almost There for Clindamycin and Intravenous Immunoglobulin?