cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex

Author:

Talbot Jessica J.1,Frisvad Jens C.2,Meis Jacques F.34ORCID,Hagen Ferry35ORCID,Verweij Paul E.46,Hibbs David E.7,Lai Felcia7,Groundwater Paul W.7,Samson Robert A.5,Kidd Sarah E.8,Barrs Vanessa R.19,Houbraken Jos5

Affiliation:

1. Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia

2. Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark

3. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital (CWZ), Nijmegen, the Netherlands

4. Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, the Netherlands

5. Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands

6. Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands

7. Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia

8. National Mycology Reference Centre, Microbiology and Infectious Diseases, SA Pathology, Adelaide, South Australia, Australia

9. Marie Bashir Institute of Biosecurity and Infectious Diseases, The University of Sydney, Sydney, New South Wales, Australia

Abstract

The past decade has seen an increase in aspergillosis in humans and animals due to Aspergillus viridinutans species complex members. Azole resistance is common to these infections, carrying a poor prognosis. cyp51A gene mutations are the main cause of acquired azole resistance in Aspergillus fumigatus . This study aimed to determine if the azole-resistant phenotype in A. viridinutans complex members is associated with cyp51A mutations or extrolite profiles.

Funder

Australian Government

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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