Gene Amplification of <i>CYP51B</i> : a New Mechanism of Resistance to Azole Compounds in Trichophyton indotineae-Reference-Cited by-同舟云学术

Gene Amplification of CYP51B : a New Mechanism of Resistance to Azole Compounds in Trichophyton indotineae

Published:2022-06-21 Issue:6 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yamada Tsuyoshi¹²^ORCID,Yaguchi Takashi³,Maeda Mari¹,Alshahni Mohamed Mahdi¹,Salamin Karine⁴,Guenova Emmanuella⁴⁵^ORCID,Feuermann Marc⁶^ORCID,Monod Michel⁴⁵^ORCID

Affiliation:

1. Teikyo University Institute of Medical Mycology, Tokyo, Japan

2. Asia International Institute of Infectious Disease Control, Teikyo University, Tokyo, Japan

3. Medical Mycology Research Center, Chiba University, Chiba, Japan

4. Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

5. Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

6. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland

Abstract

Trichophyton indotineae causes dermatophytosis that is resistant to terbinafine and azole compounds. The aim of this study was to determine the mechanisms of resistance to itraconazole (ITC) and voriconazole (VRC) in strains of T. indotineae .

Funder

The National BioResource Project-Pathogenic eukaryotic microorganisms in Japan

The Joint Usage/Research Program of the Medical Mycology Research Center, Chiba University

Institute for Fermentation, Osaka

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00059-22

Reference49 articles.

1. Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene