Liposomal Amphotericin B Displays Rapid Dose-Dependent Activity against Candida albicans Biofilms-Reference-Cited by-同舟云学术

Liposomal Amphotericin B Displays Rapid Dose-Dependent Activity against Candida albicans Biofilms

Published:2013-05 Issue:5 Volume:57 Page:2369-2371
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ramage Gordon¹,Jose Anto¹,Sherry Leighann¹,Lappin David F.¹,Jones Brian²,Williams Craig³

Affiliation:

1. Infection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

2. Department of Microbiology, Glasgow Royal Infirmary, Glasgow, United Kingdom

3. Institute of Healthcare Associated Infection, University of the West of Scotland, Ayr, United Kingdom

Abstract

ABSTRACT Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02344-12

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