Affiliation:
1. Department of Clinical Microbiology, Education and Research Centre, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland
Abstract
ABSTRACT
Synthesis of a polysaccharide adhesin by
icaADBC
-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant
Staphylococcus aureus
isolates, environmental activation of
icaADBC
did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was
icaADBC
independent. Apparently, an environmentally regulated,
ica
-independent mechanism(s) of biofilm development exists in
S. aureus
clinical isolates.
Publisher
American Society for Microbiology
Cited by
164 articles.
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