Parasite-Mediated Remodeling of the Host Microfilament Cytoskeleton Enables Rapid Egress of Trypanosoma cruzi following Membrane Rupture-Reference-Cited by-同舟云学术

Parasite-Mediated Remodeling of the Host Microfilament Cytoskeleton Enables Rapid Egress of Trypanosoma cruzi following Membrane Rupture

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ferreira Eden R.¹^ORCID,Bonfim-Melo Alexis¹^ORCID,Burleigh Barbara A.²^ORCID,Costales Jaime A.³^ORCID,Tyler Kevin M.⁴⁵^ORCID,Mortara Renato A.¹^ORCID

Affiliation:

1. Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

2. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

3. Centro de Investigación para la Salud en América Latina, Escuela de Ciencias Biológicas, Pontificia Universidad Católica del Ecuador, Quito, Ecuador

4. Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom

5. Center of Excellence for Bionanoscience Research, King Abdul Aziz University, Jeddah, Saudi Arabia

Abstract

Understanding how Trypanosoma cruzi interacts with host cells has been transformed by high-quality studies that have examined in detail the mechanisms of T. cruzi host cell invasion. In contrast, little is known about the latter stages of the parasite’s lytic cycle: how parasites egress and thereby sustain round after round of infection.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00988-21

Reference38 articles.

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2. Trypanosoma cruzi: Interaction with vertebrate cells in vitro

3. Contribuição para o estudo da anatomia patolojica da "Molestia de Carlos Chagas": (Esquizotripanoze humana ou tireoidite parazitaria)

4. Meyer H Barasa A. 1946. Life cycle of Schizotrypanum cruzi in tissue cultures. (Movie.) https://sbpz.org.br/imagens/multimidia/. Accessed 24 November 2020.

5. Trypanosoma cruzi: Parasite and Host Cell Signaling during the Invasion Process

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