NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection-Reference-Cited by-同舟云学术

NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection

Published:2020-06-30 Issue:3 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Pham Oanh H.¹,Lee Bokyung¹,Labuda Jasmine¹,Keestra-Gounder A. Marijke²^ORCID,Byndloss Mariana X.²^ORCID,Tsolis Renée M.²^ORCID,McSorley Stephen J.¹

Affiliation:

1. Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA

2. Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA

Abstract

Understanding the initiation of the inflammatory response during Chlamydia infection is of public health importance given the impact of this disease on young women in the United States. Many young women are chronically infected with Chlamydia but are asymptomatic and therefore do not seek treatment, leaving them at risk of long-term reproductive harm due to inflammation in response to infection. Our manuscript explores the role of the endoplasmic reticulum stress response pathway initiated by an innate receptor in the development of this inflammation.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00979-20

Reference32 articles.

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