Homologs of the Escherichia coli F Element Protein TraR, Including Phage Lambda Orf73, Directly Reprogram Host Transcription-Reference-Cited by-同舟云学术

Homologs of the Escherichia coli F Element Protein TraR, Including Phage Lambda Orf73, Directly Reprogram Host Transcription

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Gopalkrishnan Saumya¹,Ross Wilma¹^ORCID,Akbari Madeline S.¹,Li Xintian²,Haycocks James R. J.³,Grainger David C.³,Court Donald L.²,Gourse Richard L.¹^ORCID

Affiliation:

1. University of Wisconsin—Madison, Department of Bacteriology, Madison, Wisconsin, USA

2. RNA Biology Laboratory, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, Maryland, USA

3. University of Birmingham, Institute of Microbiology and Infection, School of Biosciences, Edgbaston, Birmingham, United Kingdom

Abstract

TraR is a distant homolog of the transcription factor DksA and the founding member of a large family of small proteins encoded by proteobacterial phages and conjugative plasmids. Reprogramming transcription during the stringent response requires the interaction of DksA not only with RNA polymerase but also with the stress-induced regulatory nucleotide ppGpp.

Funder

HHS | National Institutes of Health

UKRI | Biotechnology and Biological Sciences Research Council

Division of Cancer Prevention, National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00952-22

Reference66 articles.

1. Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes