Rapid Capsular Antigen Immunoassay for Diagnosis of Inhalational Anthrax: Preclinical Studies and Evaluation in a Nonhuman Primate Model-Reference-Cited by-同舟云学术

Rapid Capsular Antigen Immunoassay for Diagnosis of Inhalational Anthrax: Preclinical Studies and Evaluation in a Nonhuman Primate Model

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Gates-Hollingsworth Marcellene A.¹,Kolton Cari B.²,Hoffmaster Alex R.²,Meister Gabriel T.³,Moore Addie E.³,Green Heather R.¹,Pogoda Janice M.⁴,Pillai Segaran P.⁵,Kozel Thomas R.¹

Affiliation:

1. Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA

2. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

3. Battelle Biomedical Research Center, Columbus, Ohio, USA

4. Cipher Biostatistics & Reporting, Reno, Nevada, USA

5. Office of the Commissioner, Food and Drug Administration, Silver Spring, Maryland, USA

Abstract

Patient outcome in anthrax is critically dependent on early diagnosis followed by effective treatment. We describe a rapid lateral flow immunoassay that detects capsular antigen of Bacillus anthracis that is shed into blood during infection.

Funder

HHS | National Institutes of Health

U.S. Department of Homeland Security

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00931-22

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