Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication

Author:

Liu Yen-Chin123,Mok Bobo Wing-Yee12,Wang Pui12,Kuo Rei-Lin345ORCID,Chen Honglin12ORCID,Shih Shin-Ru3567ORCID

Affiliation:

1. State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, People’s Republic of China

2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong SAR, People’s Republic of China

3. Research Center for Emerging Viral Infection, College of Medicine, Chang Gung University, Taoyuan, Taiwan

4. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan

5. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan

6. Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

7. Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan

Abstract

A novel mechanistic discovery reveals that the host decay factor XRN1 contributes to influenza A virus replication, which exploits XRN1 activity to inhibit RIG-I-mediated innate immune response. Here, we identified a novel interaction between viral NS1 and host XRN1.

Funder

Chang Gung Memorial Hospital

The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan and the Ministry of Science and Technology, Taiwan

Research Grants Council of the Hong Kong SAR

The Health and Medical Research Fund of Hong Kong SAR

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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