Minimum number of pneumococci required for capsular antigen to be detectable by latex agglutination

Author:

Holloway Y1,Boersma W G1,Kuttschrütter H1,Snijder J A1

Affiliation:

1. Regional Public Health Laboratory, University Hospital, Groningen, The Netherlands.

Abstract

Forty-eight strains of Streptococcus pneumoniae were tested in vitro to determine the minimum number required for pneumococcal capsular antigen to be detectable by latex agglutination. It was found that 10(6) to 10(7) microorganisms per ml were needed and that antigen remained detectable even when viable pneumococci could no longer be demonstrated.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference30 articles.

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4. The elaboration of specific soluble substance by pneumococcus during growth;Dochez A. R.;J. Exp. Med.,1917

5. Relation of concentrations of bacteria and of bacterial antigen in cerebrospinal fluid to prognosis in patients with bacterial meningitis;Feldman W. E.;N. Engl. J. Med.,1977

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