Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan-Reference-Cited by-同舟云学术

Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lin Yi-Tsung¹²,Cheng Yi-Hsiang²,Chuang Chien¹,Chou Sheng-Hua²,Liu Wan-Hsin³,Huang Chi-Han³,Yang Tsuey-Ching⁴,Kreiswirth Barry N.⁵,Chen Liang⁵⁶

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

2. Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan

3. Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan

4. Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan

5. Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA

6. Hackensack Meridian School of Medicine, Seton Hall University, Nutley, New Jersey, USA

Abstract

Hypervirulent Klebsiella pneumoniae strains are the major cause of liver abscesses throughout East Asia, and these strains are usually antibiotic susceptible. Recently, multidrug-resistant and hypervirulent (MDR-HV) K. pneumoniae strains have emerged due to hypervirulent strains acquiring antimicrobial resistance determinants or the transfer of a virulence plasmid into a classic MDR strain. In this study, we characterized the clinical and microbiological properties of K. pneumoniae liver abscess (KPLA) caused by MDR-HV strains in Taiwan.

Funder

the Ministry of Science and Technology in Taiwan

Szu-Yuan Research Foundation of Internal Medicine

HHS | NIH | National Institute of Allergy and Infectious Diseases

Taipei Veterans General Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00174-20

Reference28 articles.