Selection of Retapamulin, a Novel Pleuromutilin for Topical Use-Reference-Cited by-同舟云学术

Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

Published:2006-11 Issue:11 Volume:50 Page:3882-3885
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rittenhouse Stephen¹,Biswas Sanjoy¹,Broskey John¹,McCloskey Lynn¹,Moore Terrance¹,Vasey Sandra¹,West Joshua¹,Zalacain Magdalena¹,Zonis Rimma¹,Payne David¹

Affiliation:

1. Department of Microbiology, MMPD CEDD, GlaxoSmithKline Pharmaceuticals, Upper Providence, Pennsylvania

Abstract

ABSTRACT The in vitro activity of retapamulin was determined and compared to that of topical and community antibiotics. The MIC 90 s of retapamulin against Staphylococcus aureus and Streptococcus pyogenes were 0.12 μg/ml and 0.016 μg/ml, respectively. Retapamulin has a low propensity to select resistance and produces an in vitro postantibiotic effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00178-06

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