Affiliation:
1. Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405
Abstract
ABSTRACT
The
PIGA
gene from
Toxoplasma gondii
has been cloned and characterized. Like mammalian PIGA, the transmembrane and C-terminal domains are sufficient to direct localization to the parasite endoplasmic reticulum. A functional copy of
PIGA
is required for tachyzoite viability, demonstrating that glycosylphosphatidylinositol biosynthesis is an essential process in
T. gondii.
Publisher
American Society for Microbiology
Subject
Molecular Biology,General Medicine,Microbiology
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