Affiliation:
1. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
Abstract
Adaptation of
Staphylococcus aureus
to host microenvironments during chronic infection involves spontaneous mutations, yet changes underlying adaptive phenotypes remain incompletely explored. Here, we employed artificial selection and whole-genome sequencing to better characterize spontaneous chromosomal mutations that alter two pathogenicity phenotypes relevant to chronic infection in
S. aureus
: intracellular invasiveness and intracellular cytotoxicity.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
10 articles.
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