Novel Genetic Constructs for Production of Recombinant HTLV-1/2 Antigens and Evaluation of Their Reactivity to Plasma Samples from HTLV-1-Infected Patients

Author:

Oliveira Ueriton Dias de12,Santos Fred Luciano Neves3ORCID,Galvão-Castro Bernardo34,Krieger Marco Aurelio5,Zanchin Nilson Ivo Tonin1ORCID

Affiliation:

1. Laboratory of Structural Biology and Protein Engineering, Carlos Chagas Institute, Oswaldo Cruz Foundation, Curitiba, Paraná, Brazil

2. Cellular and Molecular Biology Postgraduate Program, Federal University of Paraná, Curitiba, Paraná, Brazil

3. Advanced Public Health Laboratory, Gonçalo Moniz Institute, Fiocruz, Salvador, Bahia, Brazil

4. Integrated and Multidisciplinary HTLV Center, Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil

5. Molecular Biology Institute of Paraná, Curitiba, Paraná, Brazil

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) can cause life-threatening diseases for which there are no effective treatments. Prevention of HTLV-1 infection requires massive testing of pregnant women, blood for transfusion, and organs for transplantation, as well as safe sex.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

MCTI | Financiadora de Estudos e Projetos

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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