Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection-Reference-Cited by-同舟云学术

Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection

Published:2021-04-16 Issue:5 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Huang Jiachen¹²,Gingerich Aaron D.¹,Royer Fredejah¹,Paschall Amy V.³⁴,Pena-Briseno Alma¹,Avci Fikri Y.³⁴^ORCID,Mousa Jarrod J.¹²^ORCID

Affiliation:

1. Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

2. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

3. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA

4. Center for Molecular Medicine, University of Georgia, Athens, Georgia, USA

Abstract

Streptococcus pneumoniae remains a leading cause of bacterial pneumonia despite the widespread use of vaccines. While vaccines are effective at reducing the incidence of most serotypes included in vaccines, a rise in infection due to nonvaccine serotypes and moderate efficacy against some vaccine serotypes have contributed to high disease incidence.

Funder

HHS | NIH | NIH Office of the Director

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00747-20

Reference88 articles.

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