In VitroandIn VivoAssessment of Dermatophyte Acquired Resistance to Efinaconazole, a Novel Triazole Antifungal

Abstract

ABSTRACTEfinaconazole is a novel triazole antifungal drug for the topical treatment of onychomycosis, a nail infection caused mainly by dermatophytes. We assessed the potential of efinaconazole to induce resistance in dermatophytes by continuous exposure ofTrichophyton rubrumstrains to efinaconazolein vitro(12 passages) and in a guinea pig onychomycosis model (8 weeks). There was no evidence of efinaconazole resistance development in the tested strains under the experimental conditions used.