High Concentration of Raltegravir in Semen of HIV-Infected Men: Results from a Substudy of the EASIER-ANRS 138 Trial-Reference-Cited by-同舟云学术

High Concentration of Raltegravir in Semen of HIV-Infected Men: Results from a Substudy of the EASIER-ANRS 138 Trial

Published:2010-02 Issue:2 Volume:54 Page:937-939
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barau Caroline¹,Delaugerre Constance²,Braun Joséphine³,de Castro Nathalie⁴,Furlan Valérie¹,Charreau Isabelle³,Gérard Laurence⁵,Lascoux-Combe Caroline⁶,Molina Jean-Michel⁴,Taburet Anne-Marie¹

Affiliation:

1. Department of Clinical Pharmacy, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France

2. Virology, Saint-Louis Hospital, Assistance Publique Hôpitaux de Paris, Paris, France

3. INSERM SC10, Villejuif, France

4. Department of Infectious Diseases

5. Department of Clinical Immunopathology

6. Department of Internal Medicine, Saint-Louis Hospital, Assistance Publique Hôpitaux de Paris, Paris, France

Abstract

ABSTRACT Raltegravir concentrations and human immunodeficiency virus type 1 (HIV-1) RNA levels in semen samples from 10 treatment-experienced HIV-1-infected patients were measured after 24 weeks of raltegravir-based highly active antiretroviral therapy (HAART). Semen and plasma HIV-1 RNA levels were below 100 copies/ml and 50 copies/ml, respectively, in all samples. The median raltegravir concentrations in semen samples ( n = 10) and in plasma samples ( n = 9) drawn simultaneously were 345 (range, 83 to 707) ng/ml and 206 (range, 106 to 986) ng/ml, respectively. The median semen-to-plasma ratio of raltegravir concentration was 1.42 (range, 0.52 to 6.66), indicating good although variable levels of drug penetration of raltegravir in the seminal compartment.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01261-09

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