Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria-Reference-Cited by-同舟云学术

Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria

Published:2021-06-16 Issue:3 Volume:34 Page:
ISSN:0893-8512
Container-title:Clinical Microbiology Reviews
language:en
Short-container-title:Clin Microbiol Rev

Author:

Schwarz Stefan¹²^ORCID,Zhang Wanjiang³^ORCID,Du Xiang-Dang⁴^ORCID,Krüger Henrike¹,Feßler Andrea T.¹,Ma Shizhen²,Zhu Yao³,Wu Congming²,Shen Jianzhong²,Wang Yang²

Affiliation:

1. Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

2. Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China

3. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China

4. College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, People’s Republic of China

Abstract

Seven mobile oxazolidinone resistance genes, including cfr , cfr (B), cfr (C), cfr (D), cfr (E), optrA , and poxtA , have been identified to date. The cfr genes code for 23S rRNA methylases, which confer a multiresistance phenotype that includes resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A compounds. The optrA and poxtA genes code for ABC-F proteins that protect the bacterial ribosomes from the inhibitory effects of oxazolidinones.

Funder

Program for Innovative Research Team (in Science and Technology) in University of Henan Province

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Link

https://journals.asm.org/doi/pdf/10.1128/CMR.00188-20

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