Multiple Signals in the Gut Contract the Mouse Norovirus Capsid To Block Antibody Binding While Enhancing Receptor Affinity-Reference-Cited by-同舟云学术

Multiple Signals in the Gut Contract the Mouse Norovirus Capsid To Block Antibody Binding While Enhancing Receptor Affinity

Published:2021-10-27 Issue:22 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Williams Alexis N.¹,Sherman Michael B.¹,Smith Hong Q.¹,Taube Stefan²,Pettitt B. Montgomery¹,Wobus Christiane E.³^ORCID,Smith Thomas J.¹^ORCID

Affiliation:

1. University of Texas Medical Branch at Galveston, Department of Biochemistry and Molecular Biology, Galveston, Texas, USA

2. Institut für Virologie und Zellbiologie, Universität zu Lübeck, Lübeck, Germany

3. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

Abstract

The protruding domains on the calicivirus capsids are recognized by cell receptors and antibodies. We demonstrated that MNV P domains are highly mobile, and bile causes contraction onto the shell surface while allosterically blocking antibody binding.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01471-21

Reference35 articles.

1. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis

2. The State of Norovirus Vaccines

3. Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges