Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome-Reference-Cited by-同舟云学术

Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tan Yi¹,Shilts Meghan H.¹,Rosas-Salazar Christian²,Puri Vinita³,Fedorova Nadia³,Halpin Rebecca A.³,Ma Siyuan⁴,Anderson Larry J.⁵^ORCID,Peebles R. Stokes⁶,Hartert Tina V.⁶^ORCID,Das Suman R.¹⁷⁸^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Division of Infectious Diseases, J. Craig Venter Institute, Rockville, Maryland, USA

4. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

5. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

6. Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA

7. Department of Otolaryngology and Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA

8. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infections in young children and is responsible for high hospitalization rates and morbidity in infants and the elderly. To understand how the emergence of RSV viral genotypes and viral-respiratory microbiome interactions contribute to infection frequency and severity, we utilized an observational cohort designed to capture the first infant RSV infection we employed multi-omics approaches to sequence 349 RSV complete genomes and matched nasopharyngeal microbiomes.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | Centers for Disease Control and Prevention

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01472-22