iTRAQ-Based Proteomics Analysis of Human Cytomegalovirus Latency and Reactivation in T98G Cells

Author:

Cheng Shuang1,Zhao Fei23,Wen Le45,Yang Bo45,Wang Xian-Zhang16,Huang Sheng-Nan16,Jiang Xuan45,Zeng Wen-Bo1,Sun Jin-Yan1,Zhang Fu-Kun7,Shen Hong-Jie7,Fortunato Elizabeth8ORCID,Luo Min-Hua169ORCID,Cheng Han9

Affiliation:

1. State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

2. School of Basic Medical Sciences, Capital Medical University, Beijing, China

3. Chinese Institute for Brain Research, Beijing, China

4. The Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China

5. The Joint Center of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

6. University of Chinese Academy of Sciences, Beijing, China

7. Changchun Keygen Biological Products Co., Ltd., Changchun, China

8. Department of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA

9. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

Abstract

Human cytomegalovirus (HCMV) is a highly transmissible betaherpesvirus that has a prevalence of 60% to 90% worldwide. This opportunist pathogen poses a significant threat to newborns and immunosuppressed individuals.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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