Failure To Detect Chlamydia pneumoniae in Brain Sections of Alzheimer's Disease Patients-Reference-Cited by-同舟云学术

Failure To Detect Chlamydia pneumoniae in Brain Sections of Alzheimer's Disease Patients

Published:2000-02 Issue:2 Volume:38 Page:881-882
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Gieffers Jens¹,Reusche Erich²,Solbach Werner¹,Maass Matthias¹

Affiliation:

1. Institute of Medical Microbiology and Hygiene1 and

2. Institute of Pathology,2 Medical University of Lübeck, D-23538 Lübeck, Germany

Abstract

ABSTRACT A recent North American study detected Chlamydia pneumoniae in 17 of 19 brains of Alzheimer's patients and supposed a C. pneumoniae infection to be a risk factor for Alzheimer's disease (AD). In this study, we analyzed paraffin-embedded tissue samples of 20 AD patients by nested PCR and immunocytochemistry with a panel of antichlamydial antibodies and could detect neither C. pneumoniae -specific DNA nor chlamydial antigens. From our data, the presence of C. pneumoniae in the brains of Alzheimer's patients is not a common phenomenon; an association remains questionable.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.38.2.881-882.2000

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