Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion-Reference-Cited by-同舟云学术

Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

Published:1996-07 Issue:7 Volume:40 Page:1717-1719
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kan V L¹,Geber A¹,Bennett J E¹

Affiliation:

1. Infectious Diseases Section (151B), Veterans Affairs Medical Center, Washington, DC 20422, USA.

Abstract

The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.7.1717

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