A Novel Gene Cassette,aacA43, in a Plasmid-Borne Class 1 Integron

Abstract

ABSTRACTA novel gene cassette,aacA43, was identified in theaadB-aacA43-oxa10-smr2cassette array in a class 1 integron. Like related aminoglycoside-(6′)-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable on an IncL/M plasmid,aacA43was identified in only two differentKlebsiella pneumoniaestrains (14 isolates), oneEscherichia colistrain (2 isolates), and oneEnterobacter cloacaestrain in a survey of patients in a Sydney intensive care unit in 2004-2005.