Author:
Ly Neang S.,Yang Jenny,Bulitta Jurgen B.,Tsuji Brian T.
Abstract
ABSTRACTThein vitropharmacodynamics of colistin againstPseudomonas aeruginosaPAO1 wild-type and isogenic knockout strains ofphoPandpmrAwere evaluated. Colistin killing at subinhibitory concentrations was greater against thephoPandpmrAmutants than the wild type within the first 8 h: the concentration that results in 50% of maximal effect (EC50) of thepmrAmutant (0.413 mg/liter) was less than that of the wild type (0.718 mg/liter) (P< 0.05). Anin vitropharmacodynamic model simulating human colistin regimens displayed initial killing followed by regrowth in thephoPmutant and gradual regrowth in thepmrAmutant and wild type.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
25 articles.
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